Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection

Authors: McCooeye M.A.¹; Ells B.¹; Barnett D.A.¹; Purves R.W.¹; Guevremont R.¹

Source: Journal of Analytical Toxicology, Volume 25, Number 2, March 2001 , pp. 81-87(7)

Publisher: Preston Publications

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Abstract:

Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.

Language: English

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Affiliations: 1: Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R6

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