Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection

Authors: McCooeye M.A.; Ells B.; Barnett D.A.; Purves R.W.; Guevremont R.

Source: Journal of Analytical Toxicology, Volume 25, Number 2, March 2001 , pp. 81-87(7)

Publisher: Preston Publications

Abstract:

Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.

Language: English

Document Type:

Affiliations: 1: Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R6

Publication date: 2001-03-01

• The Journal of Analytical Toxicology (JAT), established in 1977 and published 9 times a year, is the international source covering a broad range of clinical, forensic, and industrial laboratory topics regarding the isolation, identification, and quantitation of potentially toxic substances.

  With an emphasis on practical application, JAT articles provide improved and novel techniques for use in clinical, forensic, workplace, sports testing (doping), and other toxicology laboratories. Articles describe newly developed methods in immunoassay testing, gas chromatography, liquid chromatography, mass spectrometry, atomic absorption spectrometry, solid and liquid phase extraction techniques, and other analytical approaches. Worldwide readership includes toxicologists, pathologists, chemists, clinicians, researchers, and educators working in medical examiner and law enforcement laboratories, hospitals, university and independent analytical laboratories, as well as the drug manufacturing industry.

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