IngentaConnect Oxidant damage to DNA and pregnancy outcome

Authors: Scholl T. O.¹; Stein T. P.¹

Source: Journal of Maternal-Fetal Medicine, Volume 10, Number 3, 1 June 2001 , pp. 182-185(4)

Publisher: Parthenon Publishing, part of the Taylor & Francis Group

Abstract:

Objective: DNA is susceptible to oxidation and is constantly being damaged and repaired in living cells. The most abundant of the nucleoside oxidation products is 8-oxo-7,8 dihydro-2 deoxyguanosine (8 OH-dG). Our objective was to determine whether oxidative damage to DNA, as measured by 8 OH-dG, is increased with poor pregnancy outcome. Method: We utilized a case-control design to study oxidative damage to DNA during an ongoing prospective study. Cases (n = 18) included all women giving birth to a low-birth-weight (< 2500 g) or growth-restricted (< 10th centile) or preterm infant (< 37 completed weeks). Controls (n = 34) were selected at random from women with normal pregnancies. Urine samples were obtained early in the third trimester (28 ± 2 weeks) and normalized to creatinine. Diet was assessed at three points during pregnancy. Results: Cases had significant (p < 0.05) increases in maternal urinary 8 OH-dG excretion at week 28, when all cases were considered and when cases were defined as those who delivered a lowbirth-weight infant. 8OH-dG excretion, in turn, correlated positively with saturated fat in the maternal diet. Conclusion: This study suggests that gravidas with poor pregnancy outcome have increased oxidative damage to their DNA early in the third trimester of pregnancy.

Keywords: PREGNANCY OUTCOME; OXIDATIVE DAMAGE; OXIDATION; LOW BIRTH WEIGHT; DIET; 8-HYDROXY-DEOXYGUANOSINE

Language: English

Document Type: Research article

Affiliations: 1: Departments of Obstetrics and Gynecology and Surgery, University of Medicine and Dentistry of New Jersey–School of Osteopathic Medicine, Stratford, New Jersey, USA

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$43.59 plus tax Refund Policy