Nicotine Blood Levels and Short-term Smoking Reduction with an Electronic Nicotine Delivery System

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Abstract:

Objectives: To evaluate nicotine delivery from the NJOY® King Bold Electronic Nicotine Delivery System (ENDS) and its short-term potential for smoking reduction or cessation. Methods: One week of ad libitum use was followed by measurements of plasma nicotine, heart rate, and craving and withdrawal after 12 hours of nicotine abstinence in 25 adult smokers not interested in quitting. Results: After 5 minutes of use, blood nicotine levels increased by a mean of 3.5 ng/mL (p < .001), heart rate increased, and craving was reduced by 55%. Cigarettes per day were reduced by 39% during the test week, and perceptions of use for reduction or cessation were positive. Conclusions: The NJOY® King Bold ENDS delivers nicotine and led to short-term smoking reduction.

Keywords: ELECTRONIC CIGARETTE; NICOTINE DELIVERY; SMOKING CESSATION

Document Type: Research Article

DOI: http://dx.doi.org/10.5993/AJHB.38.2.12

Affiliations: 1: Los Angeles Clinical Trials, Burbank, CA. Scott J. Leischow, Mayo Clinic, Scottsdale, AZ, USA. mnides@laclinicaltrials.com 2: Los Angeles Clinical Trials, Burbank, CA. Scott J. Leischow, Mayo Clinic, Scottsdale, AZ, USA

Publication date: March 1, 2014

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  • The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.

    The Journal aims to provide a comprehensive understanding of the impact of personal attributes, personality characteristics, behavior patterns, social structure, and processes on health maintenance, health restoration, and health improvement; to disseminate knowledge of holistic, multidisciplinary approaches to designing and implementing effective health programs; and to showcase health behavior analysis skills that have been proven to affect health improvement and recovery.

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