A Multicenter Phase 3 Trial of Lobeline Sulfate for Smoking Cessation
Authors: Glover, Elbert D.; Rath, Jessica M.; Sharma, Eva; Glover, Penny N.; Laflin, Molly; Tonnesen, Philip; Repsher, Lawrence; Quiring, John
Source: American Journal of Health Behavior, Volume 34, Number 1, January 2010 , pp. 101-109(9)
Publisher: PNG Publications
Abstract:Objective: To evaluate the safety and efficacy of sublingual lobeline sulfate for smoking cessation.
Methods: A multicenter (3 sites), double-blind, parallel, placebo-controlled, phase 3 smoking cessation trial of sublingual formulation of lobeline sulfate. A total of 750 smokers (250 per site) were randomized to either treatment (lobeline sulfate) or placebo with individual smoking cessation counseling lasting up to approximately 10 minutes.
Results: Efficacy revealed no statistical significance (P = 0.62) for lobeline sulfate as a smoking cessation aid.
Conclusion: Sublingual formulation of lobeline sulfate does not appear to be an effective smoking cessation aid.
Document Type: Research Article
Publication date: January 1, 2010
- The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.
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