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Bupropion SR vs Placebo for Smoking Cessation in Health Care Professionals

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Objective: To evaluate bupropion SR for smoking cessation in physicians and nurses. Methods: This double-blind prospective 26-center, 12-country trial randomized 687 subjects to smoking cessation counselling with bupropion SR or placebo for 7 weeks. The participants were followed for 52 weeks. Results: Bupropion SR was superior to placebo (50% vs 40%, P=0.013) on the 4-week primary outcome variable. Due to a high placebo response in this health care population, statistical differences were not maintained after treatment was discontinued. Conclusions: Bupropion SR is effective and well tolerated in health care professionals. Relapse prevention measures are needed to attain long-term abstinence.

Keywords: bupropion SR; healthcare professionals; smoking cessation

Document Type: Research Article


Affiliations: 1: University Medical Policlinic, Lausanne, Switzerland 2: Institute for Smokers Counseling and Smoking Cessation, Munich, Germany 3: Cardiac and Thoracic Department, Pisa University, Pisa, Italy 4: North Estonian Regional Hospital, Tallinn, Estonia 5: GlaxoSmithKline Research and Development, Greenford, Middlesex, UK

Publication date: May 1, 2005

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  • The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.

    The Journal aims to provide a comprehensive understanding of the impact of personal attributes, personality characteristics, behavior patterns, social structure, and processes on health maintenance, health restoration, and health improvement; to disseminate knowledge of holistic, multidisciplinary approaches to designing and implementing effective health programs; and to showcase health behavior analysis skills that have been proven to affect health improvement and recovery.

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