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Bupropion SR for Relapse Prevention: A “Slips-Allowed” Analysis

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Objective: To assess the efficacy of bupropion SR on smoking abstinence using a “slips allowed” analysis. Methods: Retrospective analysis, which did not consider brief episodic “slips” as a return to regular smoking, of data from a multicenter, randomized, doubleblind, placebo-controlled relapse prevention study. Results: Using a slips-allowed analysis, median time to relapse on bupropion SR was 65 weeks versus 30 weeks on placebo. This is compared to 32 and 20 weeks, respectively, using a traditional analysis not allowing for slips. Conclusion: Bupropion SR is efficacious for the prevention of smoking relapse. A slips-allowed analysis may provide a more clinically relevant assessment of efficacy.

Keywords: bupropion; relapse prevention; slips allowed analysis; smoking cessation

Document Type: Research Article


Affiliations: 1: Smoking Control, GlaxoSmithKline, Parsippany, NJ. 2: Innovaa Research, Chapel Hill, NC. 3: GlaxoSmithKline, Principal Statistician, Research Triangle Park, NC. 4: Smoking Cessaton Service, Oregon Health and Sciences University, Portland, OR. 5: Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, CA. 6: Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA. 7: Center for Behavioral Medicine, Miriam Hospital, Providence, RI.

Publication date: September 1, 2004

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  • The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.

    The Journal aims to provide a comprehensive understanding of the impact of personal attributes, personality characteristics, behavior patterns, social structure, and processes on health maintenance, health restoration, and health improvement; to disseminate knowledge of holistic, multidisciplinary approaches to designing and implementing effective health programs; and to showcase health behavior analysis skills that have been proven to affect health improvement and recovery.

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