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Comparative Testing of 5 Nicotine Systems: Initial Use and Preferences

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Objective: To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41). Methods: Subjects used each medication on arising (½ day) and resumed smoking each afternoon. Subjects rated (individually) and ranked (comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences. Results: Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs. Conclusion: Subjects had varied reactions to NRTs that may affect initiation of cessation.

Keywords: nicotine addiction; nicotine delivery systems; nicotine gum; nicotine inhaler; nicotine nasal spray; nicotine tablet; preferences

Document Type: Research Article


Affiliations: 1: Nicotine Dependence Research Unit-VA, Research Psychologist—UCLA, UCLA, Greater Los Angeles Veterans Administration, Los Angeles, CA. 2: UCLA, Greater Los Angeles Veterans Administration, Los Angeles, CA. 3: Los Angeles Clinical Trials, Los Angeles, CA.

Publication date: January 1, 2004

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  • The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.

    The Journal aims to provide a comprehensive understanding of the impact of personal attributes, personality characteristics, behavior patterns, social structure, and processes on health maintenance, health restoration, and health improvement; to disseminate knowledge of holistic, multidisciplinary approaches to designing and implementing effective health programs; and to showcase health behavior analysis skills that have been proven to affect health improvement and recovery.

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