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Impact of Prior Nicotine Replacement Therapy on Smoking Cessation Efficacy

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Objective: To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR). Methods: Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N=453) or who had used NRT at least once (N=440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS. Results: Bupropion SR showed similar efficacy in participants with or without previous use of NRT. Conclusion: Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.

Document Type: Research Article


Affiliations: 1: GlaxoSmithKline, Research Triangle Park, NC. 2: Los Angeles Clinical Trials, Los Angeles, CA. 3: Center for Tobacco Research and Intervention, University of Wisconsin Medical School, Madison WI. 4: Tobacco Control Research Branch, Bethesda MD. 5: GlaxoSmithKline, Coral Gables FL. 6: University of Nebraska Medical Centre, Omaha Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, Omaha, NE.

Publication date: May 1, 2002

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  • The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.

    The Journal aims to provide a comprehensive understanding of the impact of personal attributes, personality characteristics, behavior patterns, social structure, and processes on health maintenance, health restoration, and health improvement; to disseminate knowledge of holistic, multidisciplinary approaches to designing and implementing effective health programs; and to showcase health behavior analysis skills that have been proven to affect health improvement and recovery.

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