Recent Developments with Prophylactic Human Papillomavirus Vaccines

Authors: Lewis, Merle; Cutts, Felicity

Source: Recent Advances in Immunization, 2nd Edition, Recent Advances in Immunization, 2nd Edition , pp. 127-139(13)

Publisher: Pan American Health Organization (PAHO)

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Abstract:

One of the most important findings in cancer biology in the last quarter of the 20th century is evidence that infection of the lower genital tract with specific "high-risk" types of human papillomaviruses (HPV) causes virtually all cases of cervical carcinoma in women. Evidence also links these infections etiologically with a smaller, less defined fraction of vulvar, vaginal, anal, and penile cancers.

Prophylactic HPV vaccines have shown unprecedented levels of protection against new and persistent HPV infection and, in preliminary results to date, against related high-grade cervical lesions. Thus, these vaccines hold great promise for preventing cervical cancer. Despite the tremendous progress achieved to date in the development of HPV vaccines to prevent cervical cancer, several outstanding issues remain.

This is an article from the book Recent Advances in Immunization, 2^nd edition, which covers combination vaccines, vaccine safety, influenza control, adolescent and adult immunization, human papillomavirus vaccines, and approaches to introducing new vaccines.

Keywords: IMMUNIZATION STRATEGIES; IMMUNIZATION; VACCINES; HUMAN PAPILLOMAVIRUS VACCINE; CERVICAL CANCER; CERVICAL CANCER PREVENTION; PROPHYLACTIC HPV VACCINES

Document Type: Research article

Publication date: 2006-01-01

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