IngentaConnect Success in Vaccinating against Helicobacter pylori

Author: Czinn, Steven J.

Source: Vaccines. Preventing Disease and Protecting Health, Vaccines. Preventing Disease and Protecting Health , pp. 144-149(6)

Publisher: Pan American Health Organization (PAHO)

Abstract:

H. pylori, one of the most common bacterial infections in humans, when present in the human stomach produces gastritis and, in a subset of infected individuals, plays an important role in the pathogenesis of peptic ulcer disease and gastric cancer. Vaccines against H. pylori have only been a serious consideration since 1993; therefore most of the studies looking at vaccination against H. pylori have been done using animal models, primarily mice. Initial vaccination attempts were oral (mucosal) immunizations in an effort to promote a localized mucosal immune response in the stomach. These were very successful using a simple oral immunization consisting of H. pylori bacterial lysate and cholera toxin as a mucosal adjuvant. According to the author, the lessons learned in the field lead to thing that vaccination may be used not only to prevent infection but also can be used to eradicate or cure chronically infected individuals. This is a chapter included in Vaccines. Preventing Disease and Protecting Health, a book that celebrates the ways in which vaccines have played a role in improving the health of the world's populations.

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