Potential for Circulation of Vaccine-Derived Polioviruses

Author: Minor, Philip

Source: Vaccines. Preventing Disease and Protecting Health, Vaccines. Preventing Disease and Protecting Health , pp. 31-34(4)

Publisher: Pan American Health Organization (PAHO)

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Abstract:

An important success of the global program for the eradication of poliovirus is that the last natural wild type 2 virus was isolated in October 1999. This raises the question of the course of action to be followed once all wild type viruses have been eradicated, and, in particular, how or if vaccination can be safely stopped at some point in the future. This article discusses the evolution of vaccine strains in health vaccines; the molecular clock and the dating of common ancestral viruses; circulation vaccine-derived polioviruses; and the vaccine-derived polioviruses from immunodeficient, long-term excreters. It also gives possible solutions to the issues of vaccine-derived polioviruses. This is a chapter included in Vaccines. Preventing Disease and Protecting Health, a book that celebrates the ways in which vaccines have played a role in improving the health of the world's populations.

Keywords: Vaccines; Vaccine Development; Public Health; Immunization; Disease Prevention; Poliovirus; Serotypes; Vaccine Strains; Vaccine Derived Polioviruses; iVDPVs; Poliomyelitis; Sabine vaccine strain