Low birthweight in infants born to African HIV-infected women: relationship with maternal body weight during pregnancy
Source: Journal of Tropical Pediatrics, Volume 45, Number 3, June 1999 , pp. 152-157(6)
Publisher: Oxford University Press
The effect of maternal HIV infection on birthweight was estimated. In the prenatal clinic of the Centre Hospitalier de Kigali, HIV screening was proposed to women with a gestational age (GA) of less than 28 weeks. HIV-infected (HIV+) and uninfected (HIF-) women were recruited, when they consented. At inclusion, socioeconomic, obstetrical data, and body weight were collected a clinical examination was performed, and tests for sexually transmitted diseases (STDs) and malaria were performed. Two prenatal visits were made, at 28-32 and 32-36 weeks, with clinical data and weight measurement. At delivery, birthweight, body length, and head circumference of the infant were documented. At inclusion and at the second follow-up visit, HIV+ women (N = 177) weighted less than HIV- women (N = 194) (p = 0.004). Mean birthweight in infants born to HIV+ women was 2947 g (SD = 429) and 3104 g (SD = 461) in infants born to HIV- women (p = 0.001). Frequencies of low birthweight (LBW, weight <2500 g), prematurity (GA <27 weeks, according to Finnström score at birth), and intrauterine growth retardation (defined by LBW and GA ≥37 weeks) were higher in infants born to HIV+ women than to HIV- women (p = 0.009, 0.01, and 0.053, respectively). In multivariate logistic regression, the association between maternal HIV infection and LBW disappeared (p = 0.61), while low GA (p = 0.01) and low last prenatal weight (p = 0.01) were independant risk factors of LBW. LBW in infants born to HIV+ women could be partly attributable to impaired maternal weight. These results underline the need for nutritional surveillance and dietary counselling, hoping to improve the prognosis of pregnancy in HIV+ women, regardless of other therapeutic interventions.
Document Type: Original Article
Affiliations: 1: INSERM U, 330, Université Victor Segalen-Bordeaux 2, Bordeaux, France 2: CIDEF, Château de Longchamp, Paris, France 3: AIDS Reference Laboratory, National AIDS Control Program, Kigali, Rwanda Department of Gynaecology and Obstetrics, CHK, Kigali, Rwanda
Publication date: June 1999
- The Journal of Tropical Pediatrics provides a link between theory and practice in the field. Papers report key results of clinical and community research, and considerations of programme development. More general descriptive pieces are included when they have application to work preceeding elsewhere. The journal also presents review articles, book reviews and, occasionally, short monographs and selections of important papers delivered at relevant conferences.