Toxicological Sciences

Toxicological Implications of Modulation of Gene Expression by MicroRNAs
pp. 1-14(14)
Authors: Yokoi, Tsuyoshi; Nakajima, Miki

Application of an Integrated Testing Strategy to the U.S. EPA Endocrine Disruptor Screening Program
pp. 15-25(11)
Authors: Willett, Catherine E.; Bishop, Patricia L.; Sullivan, Kristie M.

Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator Expression in Human and Rat Placentas and Transcription Activity in Human Trophoblast Cultures
pp. 26-36(11)
Authors: Stejskalova, Lucie; Vecerova, Lenka; Perz, Laura Mesa; Vrzal, Radim; Dvorak, Zdenek; Nachtigal, Petr; Pavek, Petr

Comparative Oxidative Metabolism of BDE-47 and BDE-99 by Rat Hepatic Microsomes
pp. 37-47(11)
Authors: Erratico, Claudio A.; Moffatt, Sarah C.; Bandiera, Stelvio M.

Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure
pp. 48-57(10)
Authors: Teeguarden, Justin G.; Calafat, Antonia M.; Ye, Xiaoyum; Doerge, Daniel R.; Churchwell, Mona I.; Gunawan, Rudy; Graham, Morgan K.

Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium
pp. 58-70(13)
Authors: Thompson, Chad M.; Proctor, Deborah M.; Haws, Laurie C.; Hbert, Charles D.; Grimes, Sheila D.; Shertzer, Howard G.; Kopec, Anna K.; Hixon, J.Gregory; Zacharewski, Timothy R.; Harris, Mark A.

Tributyltin Synergizes with 20-Hydroxyecdysone to Produce Endocrine Toxicity
pp. 71-79(9)
Authors: Wang, Ying H.; Kwon, Gwijun; Li, Hong; LeBlanc, Gerald A.

Mechanistic Computational Model of Steroidogenesis in H295R Cells: Role of Oxysterols and Cell Proliferation to Improve Predictability of Biochemical Response to Endocrine Active ChemicalMetyrapone
pp. 80-93(14)
Authors: Breen, Miyuki; Breen, Michael S.; Terasaki, Natsuko; Yamazaki, Makoto; Lloyd, Alun L.; Conolly, Rory B.

The Synthetic Gestagen Levonorgestrel Impairs Metamorphosis in Xenopus laevis by Disruption of the Thyroid System
pp. 94-102(9)
Authors: Lorenz, Claudia; Contardo-Jara, Valeska; Pflugmacher, Stephan; Wiegand, Claudia; Ntzmann, Gunnar; Lutz, Ilka; Kloas, Werner

Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling
pp. 103-112(10)
Authors: Ding, Wei; Levy, Dan D.; Bishop, Michelle E.; Lyn-Cook Lascelles, E.; Kulkarni, Rohan; Chang, Ching-We; Aidoo, Anane; Manjanatha, Mugimane G.

Gender-Specific Interplay of Signaling through -Catenin and CAR in the Regulation of Xenobiotic-Induced Hepatocyte Proliferation
pp. 113-122(10)
Authors: Braeuning, Albert; Heubach, Yvonne; Knorpp, Thomas; Kowalik, Marta Anna; Templin, Markus; Columbano, Amedeo; Schwarz, Michael

Deregulation of Cancer-Related Pathways in Primary Hepatocytes Derived from DNA Repair-Deficient Xpa^/p53^/ Mice upon Exposure to Benzo[a]pyrene
pp. 123-132(10)
Authors: van Kesteren, Petra C. E.; Zwart, P. Edwin; Pennings, Jeroen L. A.; Gottschalk, W. H. Ralph; Kleinjans, Jos C. S.; van Delft, Joost H.; van Steeg, Harry; Luijten, Mirjam

Physicochemical Characterization and In Vitro Hemolysis Evaluation of Silver Nanoparticles
pp. 133-143(11)
Authors: Choi, Jonghoon; Reipa, Vytas; Hitchins, Victoria M.; Goering, Peter L.; Malinauskas, Richard A.

Nicotine Exposure during the Third Trimester Equivalent of Human Gestation: Time Course of Effects on the Central Cholinergic System of Rats
pp. 144-154(11)
Authors: Nunes-Freitas, Andr Luis; Ribeiro-Carvalho, Anderson; Lima, Carla Soares; Dutra-Tavares, Ana Carolina; Manhes, Alex C.; Lisboa, Patricia C.; Oliveira, Elaine; Gaspar de Moura, Egberto; Filgueiras, Cludio C.; Abreu-Villaa, Yael

Repeated Developmental Exposure of Mice to Chlorpyrifos Oxon Is Associated with Paraoxonase 1 (PON1)-Modulated Effects on Cerebellar Gene Expression
pp. 155-169(15)
Authors: Cole, Toby B.; Beyer, Richard P.; Bammler, Theo K.; Park, Sarah S.; Farin, Federico M.; Costa, Lucio G.; Furlong, Clement E.

Cerebellum Proteomics Addressing the Cognitive Deficit of Rats Perinatally Exposed to the Food-Relevant Polychlorinated Biphenyl 138
pp. 170-179(10)
Authors: Campagna, Roberta; Brunelli, Laura; Airoldi, Luisa; Fanelli, Roberto; Hakansson, Helen; Heimeier, Rachel A.; De Boever, Patrick; Boix, Jordi; Llansola, Marta; Felipo, Vicente; Pastorelli, Roberta

Extrapolating the Acute Behavioral Effects of Toluene from 1- to 24-h Exposures in Rats: Roles of Dose Metric and Metabolic and Behavioral Tolerance
pp. 180-192(13)
Authors: Oshiro, W. M.; Kenyon, E. M.; Gordon, C. J.; Bishop, B.; Krantz, Q. T.; Ford, J.; Bushnell, P. J.

Neurotoxicity Induced by Okadaic Acid in the Human Neuroblastoma SH-SY5Y Line Can Be Differentially Prevented by 7 and 2 Nicotinic Stimulation
pp. 193-205(13)
Authors: del Barrio, Laura; Martn-de-Saavedra, Mara Dolores; Romero, Alejandro; Parada, Esther; Egea, Javier; Avila, Jess; McIntosh, John Michael; Wonnacott, Susan; Lpez, Manuela G.

Dose-Response Assessment of Fetal Testosterone Production and Gene Expression Levels in Rat Testes Following In Utero Exposure to Diethylhexyl Phthalate, Diisobutyl Phthalate, Diisoheptyl Phthalate, and Diisononyl Phthalate
pp. 206-216(11)
Authors: Hannas, Bethany R.; Lambright, Christy S.; Furr, Johnathan; Howdeshell, Kembra L.; Wilson, Vickie S.; Gray, Leon E.

Manganese Interferes with Calcium, Perturbs ERK Signaling, and Produces Embryos with No Skeleton
pp. 217-230(14)
Authors: Pinsino, Annalisa; Roccheri, Maria Carmela; Costa, Caterina; Matranga, Valeria

A Validated Hybrid Computational Fluid Dynamics-Physiologically Based Pharmacokinetic Model for Respiratory Tract Vapor Absorption in the Human and Rat and Its Application to Inhalation Dosimetry of Diacetyl
pp. 231-246(16)
Authors: Gloede, Eric; Cichocki, Joseph A.; Baldino, Joshua B.; Morris, John B.

Assessment of the Safety and Biodistribution of a Regulated AAV2 Gene Transfer Vector after Delivery to Murine Submandibular Glands
pp. 247-255(9)
Authors: Zheng, Changyu; Voutetakis, Antonis; Goldstein, Benjamin; Afione, Sandra; Rivera, Victor M.; Clackson, Tim; Wenk, Martin L.; Boyle, Molly; Nyska, Abraham; Chiorini, John A.; Vallant, Molly; Irwin, Richard D.; Baum, Bruce J.

Differences in Tissue Distribution of HBCD Alpha and Gamma between Adult and Developing Mice
pp. 256-263(8)
Authors: Szabo, David T.; Diliberto, Janet J.; Huwe, Janice K.; Birnbaum, Linda S.

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study
pp. 264-280(17)
Authors: Monteiro-Riviere, N. A.; Wiench, K.; Landsiedel, R.; Schulte, S.; Inman, A. O.; Riviere, J. E.

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem CellDerived Cardiomyocytes
pp. 281-289(9)
Authors: Guo, Liang; Abrams, Rory M. C.; Babiarz, Joshua E.; Cohen, Jennifer D.; Kameoka, Sei; Sanders, Martin J.; Chiao, Eric; Kolaja, Kyle L.

Perfluoroalkyl Sulfonates Cause Alkyl Chain LengthDependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE3-Leiden CETP Mice
pp. 290-303(14)
Authors: Bijland, Silvia; Rensen, Patrick C.N.; Pieterman, Elsbet J.; Maas, Annemarie C.E.; van der Hoorn, Jos W.; van Erk, Marjan J.; Havekes, Louis M.; Willems van Dijk, Ko; Chang, Shu-Ching; Ehresman, David J.; Butenhoff, John L.; Princen, Hans M.G.

Erratum
pp. 304-304(1)