Toxicological Sciences

Metabolomics and Mechanisms: Sometimes the Fisher Catches a Big Fish
pp. 321-323(3)
Author: Cantor, Glenn H.

Nephrotoxicity of Uranium: Pathophysiological, Diagnostic and Therapeutic Perspectives
pp. 324-347(24)
Authors: Vicente-Vicente, Laura; Quiros, Yaremi; Prez-Barriocanal, Fernando; Lpez-Novoa, Jos Miguel; Lpez-Hernndez, Francisco Jos; Morales, Ana Isabel

Safety of Vitamins and Minerals: Controversies and Perspective
pp. 348-355(8)
Authors: Soni, Madhu G.; Thurmond, T. Scott; Miller, Edgar R.; Spriggs, Tracey; Bendich, Adrianne; Omaye, Stanley T.

ICH Guidelines: Inception, Revision, and Implications for Drug Development
pp. 356-367(12)
Authors: Wang, Tao; Jacobson-Kram, David; Pilaro, Anne M.; Lapadula, Daniel; Jacobs, Abigail; Brown, Paul; Lipscomb, John; McGuinn, William David

Exposure to Hexavalent Chromium Resulted in Significantly Higher Tissue Chromium Burden Compared With Trivalent Chromium Following Similar Oral Doses to Male F344/N Rats and Female B6C3F1 Mice
pp. 368-379(12)
Authors: Collins, Bradley J.; Stout, Matthew D.; Levine, Keith E.; Kissling, Grace E.; Melnick, Ronald L.; Fennell, Timothy R.; Walden, Ramsey; Abdo, Kamal; Pritchard, John B.; Fernando, Reshan A.; Burka, Leo T.; Hooth, Michelle J.

Alterations in Hepatic mRNA Expression of Phase II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 Alpha
pp. 380-390(11)
Authors: Lu, Hong; Gonzalez, Frank J.; Klaassen, Curtis

Functional Genetic Variants in the 3-Untranslated Region of Sulfotransferase Isoform 1A1 (SULT1A1) and Their Effect on Enzymatic Activity
pp. 391-403(13)
Authors: Yu, Xinfeng; Dhakal, Ishwori B.; Beggs, Marjorie; Edavana, Vineetha Koroth; Williams, Suzanne; Zhang, Xuemei; Mercer, Kelly; Ning, Baitang; Lang, Nicholas P.; Kadlubar, Fred F.; Kadlubar, Susan

PPAR-Dependent Activation of Cell Cycle Control and DNA Repair Genes in Hepatic Nonparenchymal Cells
pp. 404-410(7)
Authors: Qu, Aijuan; Shah, Yatrik M.; Matsubara, Tsutomu; Yang, Qian; Gonzalez, Frank J.

Effects and Mechanisms of Nonylphenol on Corticosterone Release in Rat Zona Fasciculata-Reticularis Cells
pp. 411-419(9)
Authors: Chang, Ling-Ling; Alfred Wun, Wan-Song; Wang, Paulus S.

Effect of Size Fractionation on the Toxicity of Amosite and Libby Amphibole Asbestos
pp. 420-434(15)
Authors: Duncan, Kelly E.; Ghio, Andrew J.; Dailey, Lisa A.; Bern, Amy M.; Gibbs-Flournoy, Eugene A.; Padilla-Carlin, Danielle J.; Roggli, Victor L.; Devlin, Robert B.

Emodin Triggers DNA Double-Strand Breaks by Stabilizing Topoisomerase II-DNA Cleavage Complexes and by Inhibiting ATP Hydrolysis of Topoisomerase II
pp. 435-443(9)
Authors: Li, Yan; Luan, Yang; Qi, Xinming; Li, Ming; Gong, Likun; Xue, Xiang; Wu, Xiongfei; Wu, Yuanfeng; Chen, Min; Xing, Guozhen; Yao, Jun; Ren, Jin

Caenorhabditis elegans Generates Biologically Relevant Levels of Genotoxic Metabolites from Aflatoxin B₁ but Not Benzo[a]pyrene In Vivo
pp. 444-453(10)
Authors: Leung, Maxwell C. K.; Goldstone, Jared V.; Boyd, Windy A.; Freedman, Jonathan H.; Meyer, Joel N.

An Integrated Genomic Analysis of Aryl Hydrocarbon Receptor-Mediated Inhibition of B-Cell Differentiation
pp. 454-469(16)
Authors: De Abrew, K. Nadira; Kaminski, Norbert E.; Thomas, Russell S.

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man
pp. 470-484(15)
Authors: Louisse, Jochem; de Jong, Esther; van de Sandt, Johannes J. M.; Blaauboer, Bas J.; Woutersen, Ruud A.; Piersma, Aldert H.; Rietjens, Ivonne M. C. M.; Verwei, Miriam

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development
pp. 485-500(16)
Authors: Morgan, Ryan E.; Trauner, Michael; van Staden, Carlo J.; Lee, Paul H.; Ramachandran, Bharath; Eschenberg, Michael; Afshari, Cynthia A.; Qualls, Charles W.; Lightfoot-Dunn, Ruth; Hamadeh, Hisham K.

Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes
pp. 501-509(9)
Authors: Kiang, Tony K. L.; Teng, Xiao Wei; Karagiozov, Stoyan; Surendradoss, Jayakumar; Chang, Thomas K. H.; Abbott, Frank S.

Effects of 2-Bromoethanamine on TonEBP Expression and Its Possible Role in Induction of Renal Papillary Necrosis in Mice
pp. 510-520(11)
Authors: Andres-Hernando, Ana; Lanaspa, Miguel A.; Li, Nanxing; Cicerchi, Christina; Roncal-Jimenez, Carlos; Cantor, Glenn H.; Sorribas, Victor; Rivard, Christopher J.; Berl, Tomas

Effect of N-Acetyl Cysteine and -Linolenic Acid on Sulfur Mustard Caused Impairment of In Vitro Endothelial Tube Formation
pp. 521-529(9)
Authors: Steinritz, Dirk; Blck, Birgit; Schwarz, Jana; Balszuweit, Frank; Dhr, Sandra; Ibrahim, Marwa; Bloch, Wilhelm; Thiermann, Horst; Kehe, Kai

The Glutaredoxin GLRX-21 Functions to Prevent Selenium-Induced Oxidative Stress in Caenorhabditis elegans
pp. 530-543(14)
Authors: Morgan, Kathleen L.; Estevez, Annette O.; Mueller, Catherine L.; Cacho-Valadez, Briseida; Miranda-Vizuete, Antonio; Szewczyk, Nathaniel J.; Estevez, Miguel

Benzo[a]pyrene Inhibits Angiogenic FactorsInduced v3 Integrin Expression, Neovasculogenesis, and Angiogenesis in Human Umbilical Vein Endothelial Cells
pp. 544-553(10)
Authors: Li, Ching-Hao; Cheng, Yu-Wen; Hsu, Yao-Teng; Hsu, Yu-Jeng; Liao, Po-Ling; Kang, Jaw-Jou

Aryl Hydrocarbon Receptor Nuclear Translocator in Hepatocytes Is Required for Aryl Hydrocarbon ReceptorMediated Adaptive and Toxic Responses in Liver
pp. 554-563(10)
Authors: Nukaya, Manabu; Walisser, Jacqueline A.; Moran, Susan M.; Kennedy, Gregory D.; Bradfield, Christopher A.

Clearance Kinetics of Fullerene C₆₀ Nanoparticles from Rat Lungs after Intratracheal C₆₀ Instillation and Inhalation C₆₀ Exposure
pp. 564-573(10)
Authors: Shinohara, Naohide; Nakazato, Tetsuya; Tamura, Moritaka; Endoh, Shigehisa; Fukui, Hiroko; Morimoto, Yasuo; Myojo, Toshihiko; Shimada, Manabu; Yamamoto, Kazuhiro; Tao, Hiroaki; Yoshida, Yasukazu; Nakanishi, Junko

Oxidative Stress, Inflammation, and DNA Damage in Rats after Intratracheal Instillation or Oral Exposure to Ambient Air and Wood Smoke Particulate Matter
pp. 574-585(12)
Authors: Danielsen, Pernille Hgh; Loft, Steffen; Jacobsen, Nicklas Raun; Jensen, Keld Alstrup; Autrup, Herman; Ravanat, Jean-Luc; Wallin, Hkan; Mller, Peter

Characterization of Developmental Neurotoxicity of As, Cd, and Pb Mixture: Synergistic Action of Metal Mixture in Glial and Neuronal Functions
pp. 586-601(16)
Authors: Rai, Asit; Maurya, Shailendra Kr; Khare, Priyanka; Srivastava, Abhinav; Bandyopadhyay, Sanghamitra

Chronic Ethanol Exposure Alters the Levels, Assembly, and Cellular Organization of the Actin Cytoskeleton and Microtubules in Hippocampal Neurons in Primary Culture
pp. 602-612(11)
Authors: Romero, Ana M.; Esteban-Pretel, Guillermo; Marn, Mara P.; Ponsoda, Xavier; Ballestn, Ral; Canales, Juan J.; Renau-Piqueras, Jaime

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity
pp. 613-624(12)
Authors: VanDuyn, Natalia; Settivari, Raja; Wong, Garry; Nass, Richard

Prenatal Polycyclic Aromatic Hydrocarbon Exposure Leads to Behavioral Deficits and Downregulation of Receptor Tyrosine Kinase, MET
pp. 625-634(10)
Authors: Sheng, Liu; Ding, Xinxin; Ferguson, Marcus; McCallister, Monique; Rhoades, Raina; Maguire, Mark; Ramesh, Aramandla; Aschner, Michael; Campbell, Daniel; Levitt, Pat; Hood, Darryl B.

PCB-47, PBDE-47, and 6-OH-PBDE-47 Differentially Modulate Human GABA_A and ₄₂ Nicotinic Acetylcholine Receptors
pp. 635-642(8)
Authors: Hendriks, Hester S.; Antunes Fernandes, Elsa C.; Bergman, ke; van den Berg, Martin; Westerink, Remco H. S.

Ethylene Glycol Monomethyl EtherInduced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family
pp. 643-652(10)
Authors: Takei, Makoto; Ando, Yosuke; Saitoh, Wataru; Tanimoto, Tomoe; Kiyosawa, Naoki; Manabe, Sunao; Sanbuissho, Atsushi; Okazaki, Osamu; Iwabuchi, Haruo; Yamoto, Takashi; Adam, Klaus-Peter; Weiel, James E.; Ryals, John A.; Milburn, Michael V.; Guo, Lining

Adding Insult to Injury: Effects of Xenobiotic-Induced Preantral Ovotoxicity on Ovarian Development and Oocyte Fusibility
pp. 653-666(14)
Authors: Sobinoff, Alexander P.; Pye, Victoria; Nixon, Brett; Roman, Shaun D.; McLaughlin, Eileen A.

Stimulatory Effects of Propylthiouracil on Pregnenolone Production through Upregulation of Steroidogenic Acute Regulatory Protein Expression in Rat Granulosa Cells
pp. 667-674(8)
Authors: Chen, Mei-Chih; Wang, Shyi-Wu; Kan, Shu-Fen; Tsai, Shiow-Chwen; Wu, Yu-Ching; Wang, Paulus S.

Embryotoxicant-Specific Transcriptomic Responses in Rat Postimplantation Whole-Embryo Culture
pp. 675-685(11)
Authors: Robinson, Joshua F.; van Beelen, Vincent A.; Verhoef, Aart; Renkens, Marc F. J.; Luijten, Mirjam; van Herwijnen, Marcel H. M.; Westerman, Anja; Pennings, Jeroen L. A.; Piersma, Aldert H.

Teratogen-Induced Oxidative Stress Targets Glyceraldehyde-3-Phosphate Dehydrogenase in the Organogenesis Stage Mouse Embryo
pp. 686-695(10)
Authors: Schlisser, Ava E.; Yan, Jin; Hales, Barbara F.

Deviations from Habers Law for Multiple Measures of Acute Lung Injury in Chlorine-Exposed Mice
pp. 696-703(8)
Authors: Hoyle, Gary W.; Chang, Weiyuan; Chen, Jing; Schlueter, Connie F.; Rando, Roy J.

Analysis of the CYP1A1 mRNA Dose-Response in Human Keratinocytes Indicates that Relative Potencies of Dioxins, Furans, and PCBs Are Species and Congener Specific
pp. 704-715(12)
Authors: Sutter, Carrie H.; Bodreddigari, Sridevi; Sutter, Thomas R.; Carlson, Erik A.; Silkworth, Jay B.

Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound
pp. 716-731(16)
Authors: Andersen, Melvin E.; Clewell, Harvey J.; Bermudez, Edilberto; Dodd, Darol E.; Willson, Gabrielle A.; Campbell, Jerry L.; Thomas, Russell S.

Erratum
pp. 732-732(1)