High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification
Source: QJM: An International Journal of Medicine, Volume 101, Number 6, 14 June 2008 , pp. 475-477(3)
Publisher: Oxford University Press
Abstract:Vitamin B12 deficiency may be an independent risk factor for neural tube defects (NTD). We determined the prevalence of biochemical B12 deficiency (<125 pmol/l) among 10 622 Ontarian women aged 15–46 years who underwent concomitant testing of serum bhCG and B12 9 years after the implementation of Canadian folic acid flour fortification. The overall prevalence of biochemical B12 deficiency was 7.4%. Relative to non-pregnant women, the adjusted odds ratio (95% confidence interval) of biochemical B12 deficiency was 0.78 (0.60–1.0) among women pregnant 28 days gestation or less and was 1.4 (1.1–1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered.
Document Type: Research Article
Affiliations: 1: Department of Medicine, Department of Obstetrics and Gynecology and Department of Health Policy Management and Evaluation, St Michael's Hospital University of Toronto, Toronto, , 2: Strategies and Innovation, Gamma-Dynacare Medical Laboratories, Brampton, Ontario, Canada, , 3: School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, and , 4: Applied Health Research Centre, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada,
Publication date: 2008-06-14
- QJM is a long-established, leading general medical journal. It focuses on internal medicine and publishes peer-reviewed articles which promote medical science and practice. Published monthly, QJM includes original papers, editorials, reviews, commentary papers to air controversial issues, and a correspondence column.