Improvement of factor VII clotting activity following long-term NCPAP treatment in obstructive sleep apnoea syndrome
Authors: Chin, K; Kita, H; Noguchi, T; Otsuka, N; Tsuboi, T; Nakamura, T; Shimizu, K; Mishima, M; Ohi, M
Source: QJM: An International Journal of Medicine, Volume 91, Number 9, September 1998 , pp. 627-633(7)
Publisher: Oxford University Press
Abstract:Obstructive sleep apnoea syndrome (OSAS) is a very common disorder. Patients with OSAS are at an increased risk for cardiovascular events. It has also been reported that a 25% rise in factor VII clotting activity (FVIIc) is associated with a 55% increase in ischaemic heart disease death during the first 5 years. We examined the effects of nasal continuous positive airway pressure (NCPAP) treatment on FVIIc in patients with OSAS. FVIIc was investigated prospectively in 15 patients with OSAS before (mean ± SEM apnoea and hypopnoea index (AHI) 61.5 ± 4.2 and after (AHI 3.0 ± 0.9) NCPAP treatment for immediate relief, at 1 month after treatment and at over 6 months. FVIIc levels gradually decreased after NCPAP treatment. After 6 months of NCPAP treatment, FVIIc levels had decreased significantly (before 141.1 ± 11.7% vs. after 6 months 110.7 ± 6.2%; p<0.01). Six of the seven patients whose FVIIc levels were over 140% before the NCPAP treatment had FVIIc levels below 130% after 6 months or 1 year of NCPAP treatment. This decrease in FVIIc after long-term NCPAP treatment could improve mortality in OSAS patients. If patients, especially obese ones, present with high FVIIc of unknown origin, it would be prudent to check for OSAS.
Document Type: Research article
Publication date: 1998-09-01
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