Podocyte proliferation and differentiation in glomerular disease: role of cell-cycle regulatory proteins

Authors: Griffin S.V.; Petermann A.T.; Durvasula R.V.; Shankland S.J.

Source: Nephrology Dialysis Transplantation, Volume 18, Number 6, August 2003 , pp. vi8-vi13(1)

Publisher: Oxford University Press

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Abstract:

Injury to the podocyte underlies many forms of glomerular disease. In contrast to mesangial and endothelial cells, podocytes do not typically proliferate. Moreover, the lack of proliferation is thought to underlie the development of glomerulosclerosis. Studies have recently shown that the lack of podocyte proliferation is due to an increase in cyclin-dependent kinase inhibitors, which arrest the cell cycle. Current work is aimed at further delineating the mechanisms regulating podocyte proliferation.

Keywords: cell cycle; cyclin; glomerular epithelial cell; kidney; podocyte proliferation

Document Type: Research article

DOI: 10.1093/ndt/gfg1069

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