Derivation and differentiation of glomerular endothelial cells

Authors: Abrahamson D.R.; Robert B.

Source: Nephrology Dialysis Transplantation, Volume 18, Number 6, August 2003 , pp. vi2-vi7(6)

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Abstract:

Data on the embryonic derivation of metanephric endothelial cells are reviewed, paying particular attention to results obtained from anterior chamber and intrarenal grafts of embryonic kidneys. Most of the evidence supports an intrinsic origin of the endothelium, which probably differentiates from metanephric mesenchyme. The roles of several growth factor receptor/ligand systems are also discussed, with an emphasis on the VEGF receptors, Flk1 and neuropilin-1.

Keywords: angiogenesis; differentiation; endothelial cells; Flk1; glomerulus; neuropilin-1; vasculogenesis; VEGF

Document Type: Research article

DOI: http://dx.doi.org/10.1093/ndt/gfg1056

Publication date: 2003-08-01

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Nephrology Dialysis Transplantation is one of the world's leading journals devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world.