Adenovirus-mediated functional gene transfer into parathyroid cells in vivo and in vitro

Authors: Iwasaki Y.¹; Kakuta T.²; Haruguchi H.³; Fukuda N.⁴; Kurokawa K.²; Fukagawa M.⁵

Source: Nephrology Dialysis Transplantation, Volume 18, Number 3, March 2003 , pp. iii18-iii22(5)

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Abstract:

Chronic renal failure patients usually develop secondary hyperparathyroidism and, as the disease progresses, there is a decrease in the number of vitamin D and calcium-sensing receptors (CaRs) in the parathyroid glands. Parathyroid cell function can be controlled if a functional gene is transferred into these cells using an adenovirus vector. Vitamin D or CaR genes transferred by the infected adenovirus vector induced a reduction in parathyroid hormone secretion. These results suggest that adenovirus-mediated gene transfer is a useful technique for control of parathyroid cell function.

Keywords: adenovirus; calcium-sensing receptor; functional gene transfer; vitamin D receptor

Document Type: Research article

DOI: http://dx.doi.org/10.1093/ndt/gfg1005

Affiliations: 1: Division of Nephrology and Clinical Research Center, Tokyo Teishin Hospital, Tokyo, 2: Division of Nephrology, Tokai University School of Medicine, Bouseidai, Isehara-city, 3: Third Department of Surgery, Tokyo Women's Medical College Hospital, Tokyo, 4: Division of Nephrology, Tokyo University School of Medicine, Tokyo and 5: Division of Nephrology and Dialysis Center, Kobe University School of Medicine, Japan

Publication date: 2003-03-01

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Nephrology Dialysis Transplantation is one of the world's leading journals devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world.