Quality of sleep and health-related quality of life in haemodialysis patients

Authors: Iliescu E.A.¹; Coo H.²; McMurray M.H.³; Meers C.L.³; Quinn M.M.²; Singer M.A.¹; Hopman W.M.²

Source: Nephrology Dialysis Transplantation, Volume 18, Number 1, January 2003 , pp. 126-132(7)

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Abstract:

Background. Sleep complaints are common in haemodialysis patients. In the general population, insomnia impacts negatively on health-related quality of life (HRQoL). The objective of this study was to examine the association between quality of sleep and HRQoL in haemodialysis patients independent of known predictors of HRQoL.

Methods. Quality of sleep was measured using the Pittsburgh Sleep Quality Index (PSQI) and HRQoL was measured using the Medical Outcomes Study 36-item Short Form (SF-36) in 89 haemodialysis patients.

Results. Sixty-three (71%) subjects were ‘poor sleepers' (global PSQI >5). The SF-36 mental component summary (MCS) and physical component summary (PCS) correlated inversely with the global PSQI score (MCS, r=-0.28, P<0.01; PCS, r=-0.45, P<0.01). The PCS score also correlated with age (r=-0.24, P=0.02), haemoglobin (r=0.21, P=0.048) and comorbidity (r=-0.40, P<0.01), and mean PCS was lower in depressed subjects (26.2 vs 35.9, P=0.02). Subjects with global PSQI >5 had a higher prevalence of depression, lower haemoglobin and lower HRQoL in all SF-36 domains. The global PSQI score was a significant independent predictor of the MCS and PCS after controlling for age, sex, haemoglobin, serum albumin, comorbidity and depression in multivariate analysis.

Conclusions. Poor sleep is common in dialysis patients and is associated with lower HRQoL. We hypothesize that end-stage renal disease directly influences quality of sleep, which in turn impacts on HRQoL.

Keywords: chronic renal failure; comorbidity; haemodialysis; quality of life; sleep

Document Type: Original article

Affiliations: 1: Department of Medicine, Queen's University, Kingston, Ontario, 2: MacKenzie Health Services Research Group, Queen's University, Kingston, Ontario, 3: End Stage Renal Disease Program, Kingston General Hospital, Kingston, Ontario and

Publication date: 2003-01-01

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Nephrology Dialysis Transplantation is one of the world's leading journals devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world.

Quality of sleep and health-related quality of life in haemodialysis patients

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