Low free thyroxine concentratios and deficient nocturnal surge of thyroid-stimulating hormone in haemodialysed patients compared with undialysed patients
Authors: Nakajima, T.1; Suzuki, T.1; Ando, S.2; Genma, R.2; Nakamura, H.2; Hishida, A.1; Yonemura, K.
Source: Nephrology Dialysis Transplantation, Volume 15, Number 5, May 2000 , pp. 668-672(5)
Publisher: Oxford University Press
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Abstract:
Background. There is little information on the differences in pituitary–thyroid function between undialysed and haemodialysed patients.Methods. Serum concentrations of free thyroxine (T4) and free triiodothyronine (T3), measured by enhanced chemiluminescence immunoassay, and thyroid-stimulating hormone (TSH) were compared in undialysed (n=22) and haemodialysed patients (n=85). The response of the serum TSH concentration to exogenously administered thyrotropin-releasing hormone (TRH) and circadian variation in serum TSH were also studied in the two groups.Results. Serum free T4 concentration was significantly lower in haemodialysed than in undialysed patients (1.02±0.02 vs 1.33±0.06 ng/dl, P<0.0001). Serum concentrations of free T3 and TSH were essentially the same for the two groups. The response of serum TSH concentration to TRH was basically the same. Serum TSH concentration in undialysed patients during the night and in the morning were 142.4±15.4% and 121.7±4.1% of that during the day, the differences being significantly different. A nocturnal surge of TSH was not observed in haemodialysed patients.Conclusions. Low serum free T4 concentration and a deficient nocturnal surge of TSH were found in haemodialysed patients compared with undialysed patients. The deficient nocturnal surge of TSH may contribute to the lower serum free T4 concentration in haemodialysed patients.Keywords: chronic renal failure; haemodialysis; thyroid horm
Document Type: Original article
Affiliations: 1: First Department of Medicine and 2: Second Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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