The Nuclear Protein Database (NPD): sub-nuclear localisation and functional annotation of the nuclear proteome

Authors: Dellaire, G.¹; Farrall, R.¹; Bickmore, W.A.²

Source: Nucleic Acids Research, Volume 31, Number 1, 01 January 2003 , pp. 328-330(3)

Publisher: Oxford University Press

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Abstract:

The Nuclear Protein Database (NPD) is a curated database that contains information on more than 1300 vertebrate proteins that are thought, or are known, to localise to the cell nucleus. Each entry is annotated with information on predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. In addition, information on the sub-nuclear localisation of each protein is provided and the biological and molecular functions are described using Gene Ontology (GO) terms. The database is searchable by keyword, protein name, sub-nuclear compartment and protein domain/motif. Links to other databases are provided (e.g. Entrez, SWISS-PROT, OMIM, PubMed, PubMed Central). Thus, NPD provides a gateway through which the nuclear proteome may be explored. The database can be accessed at http://npd.hgu.mrc.ac.uk and is updated monthly.

Document Type: Research article

DOI: http://dx.doi.org/10.1093/nar/gkg018

Affiliations: 1: MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK 2: *To whom correspondence should be addressed., Fax: +44 131 343 2620, Email: wendy.bickmore@hgu.mrc.ac.uk

Publication date: 2003-01-01

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Nucleic Acids Research (NAR) is a fully Open Access journal, providing rapid publication of leading edge research into the nucleic acids under the following categories: chemistry, computational biology, genomics, molecular biology, nucleic acid enzymes, RNA and structural biology. There is a Survey and Summary section, and methods papers are published
in NAR Methods Online. Each year the first issue is devoted to biological databases, and a later issue to relevant web-based software resources.