KinMutBase, a database of human disease‐causing protein kinase mutations
Authors: Stenberg, Kaj A. E.; Riikonen, Pentti T.; Vihinen, Mauno
Source: Nucleic Acids Research, Volume 27, Number 1, 01 January 1999 , pp. 362-364(3)
Publisher: Oxford University Press
Abstract:KinMutBase (http://www.uta.fi/laitokset/imt/KinMutBase.html ) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signalling molecules, in which mutations can lead into diseases including, e.g., immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contains information for nine protein tyrosine kinases. There are altogether 170 entries representing 273 families and 403 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non‐homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online submission.
Document Type: Research Article
Affiliations: Institute of Medical Technology, University of Tampere, PO Box 607, FIN‐33101 Tampere, Finland
Publication date: 1999-01-01
- Nucleic Acids Research (NAR) is a fully Open Access journal, providing rapid publication of leading edge research into the nucleic acids under the following categories: chemistry, computational biology, genomics, molecular biology, nucleic acid enzymes, RNA and structural biology. There is a Survey and Summary section, and methods papers are published
in NAR Methods Online. Each year the first issue is devoted to biological databases, and a later issue to relevant web-based software resources.