Organising multi‐dimensional biological image information: The BioImage Database
Authors: Carazo, J. M.; Stelzer, E. H. K.1; Engel, A.2; Fita, I.3; Henn, C.4; Machtynger, J.5; McNeil, P.6; Shotton, D. M.7; Chagoyen, M.; de Alarcón, P. A.; Fritsch, R.1; Heymann, J. B.2; Kalko, S.; Pittet, J. J.4; Rodriguez‐Tomé, P.6; Boudier, T.7
Source: Nucleic Acids Research, Volume 27, Number 1, 01 January 1999 , pp. 280-283(4)
Publisher: Oxford University Press
Abstract:Nowadays it is possible to unravel complex information at all levels of cellular organization by obtaining multi‐dimensional image information. At the macromolecular level, three‐dimensional (3D) electron microscopy, together with other techniques, is able to reach resolutions at the nanometer or subnanometer level. The information is delivered in the form of 3D volumes containing samples of a given function, for example, the electron density distribution within a given macromolecule. The same situation happens at the cellular level with the new forms of light microscopy, particularly confocal microscopy, all of which produce biological 3D volume information. Furthermore, it is possible to record sequences of images over time (videos), as well as sequences of volumes, bringing key information on the dynamics of living biological systems. It is in this context that work on BioImage started two years ago, and that its first version is now presented here. In essence, BioImage is a database specifically designed to contain multi‐dimensional images, perform queries and interactively work with the resulting multi‐dimensional information on the World Wide Web, as well as accomplish the required cross‐database links. Two sister home pages of BioImage can be accessed at http://www.bioimage.org and http://www‐embl.bioimage.org
Document Type: Research Article
Affiliations: 1: European Molecular Biology Laboratory (EMBL), Postfach 102209, D‐69012 Heidelberg, Germany, 2: M. E. Müller Institute for Microscopic Structural Biology, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH‐4056 Basel, Switzerland, 3: Centro de Investigación y Desarrollo‐CSIC, Jordi Girona Salgado 18–26, E‐08034 Barcelona, Spain, 4: Advanced Technology Center Silicon Graphics Inc. Chemin des Rochettes 2, CH‐2016 Cortaillod, Switzerland, 5: Informix Software Ltd., 6 New Square, Bedfont Lakes, Feltham TW14 8HA, UK, 6: The European BioInformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 7: Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Publication date: 01 January 1999
- Nucleic Acids Research (NAR) is a fully Open Access journal, providing rapid publication of leading edge research into the nucleic acids under the following categories: chemistry, computational biology, genomics, molecular biology, nucleic acid enzymes, RNA and structural biology. There is a Survey and Summary section, and methods papers are published
in NAR Methods Online. Each year the first issue is devoted to biological databases, and a later issue to relevant web-based software resources.
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- In this Subject: Anatomy & Physiology
- By this author: Carazo, J. M. ; Stelzer, E. H. K. ; Engel, A. ; Fita, I. ; Henn, C. ; Machtynger, J. ; McNeil, P. ; Shotton, D. M. ; Chagoyen, M. ; de Alarcón, P. A. ; Fritsch, R. ; Heymann, J. B. ; Kalko, S. ; Pittet, J. J. ; Rodriguez‐Tomé, P. ; Boudier, T.