UTRdb: a specialized database of 5′ and 3′ untranslated regions of eukaryotic mRNAs
Source: Nucleic Acids Research, Volume 27, Number 1, 01 January 1999 , pp. 188-191(4)
Publisher: Oxford University Press
Abstract:The 5′ and 3′ untranslated regions of eukaryotic mRNAs may play a crucial role in the regulation of gene expression controlling mRNA localization, stability and translational efficiency. For this reason we developed UTRdb (http://bigarea.area.ba.cnr.it:8000/BioWWW/#UTRdb ), a specialized database of 5′ and 3′ untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs. Furthermore, UTRdb entries have been annotated for the presence of repetitive elements.
Document Type: Research Article
Affiliations: 1: Dipartimento di Biologia, D.B.A.F., Università della Basilicata, via Anzio 10, 85100 Potenza, Italy, 2: Area di Ricerca di Bari, C.N.R., via Amendola 166/5, 70126 Bari, Italy, 3: Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, via Orabona 4, 70126 Bari, Italy and 4: National Center for Biotechnology Information, NLM‐NIH, Bethesda, MD, USA
Publication date: 1999-01-01
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