IngentaConnect Induction effects of sulfur dioxide inhalation on chromosomal abe...

Authors: Meng Z.¹; Zhang B.¹

Source: Mutagenesis, Volume 17, Number 3, May 2002 , pp. 215-217(3)

Abstract:

To investigate the induction of chromosome aberrations (CA) in mouse bone marrow cells by sulfur dioxide (SO₂) inhalation, mice were treated by SO₂ exposure for 4 h/day for 7 days at various concentrations of SO₂, then mitotic indices and CA in mouse bone marrow cells were analyzed. The present results show that SO₂ might increase the frequencies of CA and aberrant cells in mouse bone marrow in a dose-dependent manner. The frequencies (%) of aberrant cells in mouse bone marrow induced by SO₂ at concentrations of 0, 7, 14, 28 and 56 mg/m³ were 1.81, 3.00, 3.58, 4.26, 4.86, respectively. At low concentrations SO₂ induced only chromatid-type CA, while at high concentrations SO₂ induced both chromatid-type and chromosome-type CA. SO₂ inhalation decreased the mitotic indices of bone marrow cells. The results imply that SO₂ inhalation may inhibit mitoses and increase CA frequencies of bone marrow cells and that it is a clastogenetic and genotoxic agent. Long exposure to SO₂ pollution at low concentrations in the environment may be a potential risk for induction of cytogenetic damage in vivo in humans.

Language: English

Document Type: Original article

Affiliations: 1: Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006, People's Republic of China

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Induction effects of sulfur dioxide inhalation on chromosomal aberrations in mouse bone marrow cells