Double Cancer of Gall Bladder and Bile Duct not Associated with Anomalous Junction of the Pancreaticobiliary Duct System

Authors: Hori, Hiiroshige; Ajiki, Tetsuo; Fujita, Tsunenori; Okazaki, Taro; Suzuki, Yasuyuki; Kuroda, Yoshikazu; Fujimori, Takahiro

Source: Japanese Journal of Clinical Oncology, Volume 36, Number 10, October 2006 , pp. 638-642(5)

Publisher: Oxford University Press

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Abstract:

Background: Simultaneous double cancers of the biliary tract are rare. Most of them are thought to be associated with pancreaticobiliary maljunction (PBM); however, the characteristics of tumours without PBM are still unclear.

Methods: Histology, immunoreactivity with carcinoembryonic antigen, carbohydrate antigen 19-9 and p53 and mutations in the K-ras gene were examined in tumours resected from cases of simultaneous double cancers of the biliary tract.

Results: Four cases of simultaneous double cancers of the biliary tract were identified among 108 patients with biliary tract cancer (3.7%). None of the four cases associated with PBM, and the results of histological, immunohistochemical and genetic examinations differed between the bile duct and gall bladder cancers in each case.

Conclusion: Even when they do not associate with PBM, double cancers in the biliary tract are more likely to be the result of multicentric development.

Keywords: double cancer; gall bladder; bile duct; K-ras; p53

Document Type: Research article

DOI: http://dx.doi.org/10.1093/jjco/hyl077

Publication date: 2006-10-01

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JJCO was established in 1971 as the first journal from Japan to publish clinical research on cancer in English. It was a biannual journal for the first 11 years, and as the number of submissions increased, it became quarterly in 1983 and bimonthly in 1991. Since 1998, the JJCO has been published monthly.