Secondary Amyloidosis and Eosinophilia in a Patient with Uterine Leiomyosarcoma

Authors: Onishi, Sachiko; Hojo, Nobumasa; Sakai, Ikuya; Matsumoto, Takashi; Watanabe, Akihito; Miyazaki, Tatsuhiko; Ito, Mitsuko R.; Nose, Masato; Fujita, Shigeru

Source: Japanese Journal of Clinical Oncology, Volume 35, Number 10, 10 2005 , pp. 617-621(5)

Publisher: Oxford University Press

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Abstract:

We report a rare case demonstrating the relationship between secondary amyloidosis and uterine leiomyosarcoma. A 59-year-old female with high fever was referred to our hospital. Laboratory tests revealed increased white blood cells, eosinophilia and an accelerated erythrocyte sedimentation rate. Endoscopic examination of the stomach and colon revealed amyloid deposits in their mucosa. The patient showed no symptoms that suggested amyloidosis. No other organs or tissues were surveyed for amyloid deposition. Ga scintigraphy, computed tomography and magnetic resonance imaging suggested necrotic infectious leiomyoma of the uterus, which was considered to be the cause of the fever. The patient underwent total hysterectomy. The histological diagnosis of the mass revealed a low-grade uterine leiomyosarcoma with necrosis. Amyloid deposits in the gastric mucosa disappeared 1 year after the operation. In this case, amyloid deposition was detected by endoscopic biopsy before clinical manifestations. The deposition was reversible and was successfully treated. Thus, it is logical and useful to undertake endoscopic mucosa biopsy to check for amyloid deposition in patients with systemic inflammation, whose serum amyloid A protein level has been high for several months. In addition, peripheral eosinophilia was also detected in this case. Although eosinophilia associated with malignant tumor has been recognized, it is an uncommon occurrence.

Keywords: leiomyosarcoma; uterus; secondary amyloidosis; serum amyloid A protein

Document Type: Research article

DOI: http://dx.doi.org/10.1093/jjco/hyi156

Publication date: 2005-10-01

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JJCO was established in 1971 as the first journal from Japan to publish clinical research on cancer in English. It was a biannual journal for the first 11 years, and as the number of submissions increased, it became quarterly in 1983 and bimonthly in 1991. Since 1998, the JJCO has been published monthly.

Secondary Amyloidosis and Eosinophilia in a Patient with Uterine Leiomyosarcoma

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