Management of Malignant Pericardial Effusion with Instillation of Mitomycin C in Non-small Cell Lung Cancer

Authors: Kaira, Kyoichi¹; Takise, Atsushi¹; Kobayashi, Go¹; Utsugi, Mitsuyoshi¹; Horie, Takeo¹; Mori, Takanori¹; Imai, Hisao¹; Inazawa, Masahito¹; Mori, Masatomo²

Source: Japanese Journal of Clinical Oncology, Volume 35, Number 2, February 2005 , pp. 57-60(4)

Publisher: Oxford University Press

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JJCO was established in 1971 as the first journal from Japan to publish clinical research on cancer in English. It was a biannual journal for the first 11 years, and as the number of submissions increased, it became quarterly in 1983 and bimonthly in 1991. Since 1998, the JJCO has been published monthly.

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By this author: Kaira, Kyoichi ; Takise, Atsushi ; Kobayashi, Go ; Utsugi, Mitsuyoshi ; Horie, Takeo ; Mori, Takanori ; Imai, Hisao ; Inazawa, Masahito ; Mori, Masatomo

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Abstract:

Background: To evaluate the clinical efficacy and safety of mitomycin C in the local control of malignant pericardial effusion, we carried out a trial of pericardial drainage with local instillation of mitomycin C in eight patients who suffered from cardiac tamponade or symptomatic large pericardial effusion caused by advanced non-small cell lung cancer.

Methods: After complete removal of the pericardial effusion by an ultrasound-guided inserted catheter, 2 mg of mitomycin C was instilled into the pericardial space via the catheter.

Results: The drainage catheter was successfully removed in all patients. The duration of pericardial drainage ranged from 7 to 14 days (median 10.5 days). Six of the eight patients achieved a complete remission of pericardial effusions without any adverse effects.

Conclusion: Intrapericardial instillation of 2 mg of mitomycin C was feasible and demonstrated a promising response against malignant pericardial effusion resulting from non-small cell lung cancer.

Keywords: malignant pericardial effusion; mitomycin C; lung cancer; intrapericardial instillation; pericardial drainage

Document Type: Research article

DOI: 10.1093/jjco/hyi019

Affiliations: 1: Department of Respiratory Medicine, Maebashi Red Cross Hospital and 2: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan