Authors: Takamochi, Kazuya¹; Yokose, Tomoyuki¹; Yoshida, Junji²; Nishimura, Mitsuyo²; Ohmatsu, Hironobu²; Nagai, Kanji²; Nishiwaki, Yutaka²; Ochiai, Atsushi¹

Source: Japanese Journal of Clinical Oncology, Volume 33, Number 1, 1 January 2003 , pp. 10-13(4)

Publisher: Oxford University Press

Abstract:

Background: The aim was to investigate the prevalence of intratumoral calcification in large cell neuroendocrine carcinoma (LCNEC) and to review computed tomography (CT) and histological findings.

Patients and methods: From August 1992 through March 2000, 35 out of 1183 surgically resected lung cancer patients were histologically diagnosed as having LCNEC at our institute. We reviewed the plain radiographs and CT scans of these 35 LCNEC patients. In LCNEC cases with intratumoral calcification, we examined the size, number, distribution and pattern of intratumoral calcifications visible on the CT scans and the histological features.

Results: Three cases (9%) exhibited calcification. The calcifications were recognized by CT scans alone. The CT scans showed punctate or eccentric intratumoral calcifications, which are considered to be a malignant feature, in all three cases. In two cases, the calcifications were histologically confirmed to be located within the necrotic areas of a tumor nest.

Conclusion: We found three LCNEC cases with intratumoral calcification. The prevalence of LCNEC calcification was similar to that in previous reports on lung cancer. The mechanism of the intratumoral calcification in our LCNEC cases is speculated to be dystrophic calcification.

Document Type: Research article

Affiliations: 1: Pathology Division, National Cancer Center Research Institute East, Kashiwa, Chiba and 2: Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

Publication date: 2003-01-01

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• JJCO was established in 1971 as the first journal from Japan to publish clinical research on cancer in English. It was a biannual journal for the first 11 years, and as the number of submissions increased, it became quarterly in 1983 and bimonthly in 1991. Since 1998, the JJCO has been published monthly.

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• By this author: Takamochi, Kazuya ;  Yokose, Tomoyuki ;  Yoshida, Junji ;  Nishimura, Mitsuyo ;  Ohmatsu, Hironobu ;  Nagai, Kanji ;  Nishiwaki, Yutaka ;  Ochiai, Atsushi

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