Decreased Expression of Catalase mRNA in Thyroid Anaplastic Carcinoma

Authors: Hasegawa, Yukiko¹; Takano, Toru¹; Miyauchi, Akira²; Matsuzuka, Fumio²; Yoshida, Hiroshi²; Kuma, Kanji²; Amino, Nobuyuki¹

Source: Japanese Journal of Clinical Oncology, Volume 33, Number 1, 1 January 2003 , pp. 6-9(4)

Publisher: Oxford University Press

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Abstract:

Background: A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas.

Methods: To clarify the expression of antioxidant-related enzymes in thyroid anaplastic carcinomas, the expression levels of catalase, copper and zinc superoxide dismutase and manganese superoxide dismutase mRNA in 85 benign and malignant thyroid tissues were measured by means of real-time quantitative reverse transcription-polymerase chain reaction.

Results: Decreased expression levels of catalase and copper and zinc superoxide dismutase mRNAs, but not manganese mRNA, were observed in five anaplastic carcinomas compared with normal thyroid tissues and differentiated tumors.

Conclusion: These results suggest the possibility that anaplastic carcinoma cells are more likely to suffer damage by oxygen free radicals than normal thyroid cells or differentiated tumor cells.

Document Type: Research article

Affiliations: 1: Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka and 2: Kuma Hospital, Kobe, Japan

Publication date: 2003-01-01

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JJCO was established in 1971 as the first journal from Japan to publish clinical research on cancer in English. It was a biannual journal for the first 11 years, and as the number of submissions increased, it became quarterly in 1983 and bimonthly in 1991. Since 1998, the JJCO has been published monthly.