Turners syndrome and fertility: current status and possible putative prospects
Authors: R. Abir; B. Fisch; R. Nahum; R. Orvieto; S. Nitke
Source: Human Reproduction Update, Volume 7, Number 6, December 2001 , pp. 603-610(8)
Publisher: Oxford University Press
Abstract:Women with Turners syndrome should be carefully followed throughout life. Growth hormone therapy should be started at age 25 years. Hormone replacement therapy for the development of normal female sexual characteristics should be started at age 1215 years and continued for the long term to prevent coronary artery disease and osteoporosis. Most women with Turners syndrome have ovarian dysgenesis; therefore, they are usually infertile, and in very rare cases have spontaneous menses followed by early menopause. Only 2% of the women have natural pregnancies, with high rates of miscarriages, stillbirths and malformed babies. Their pregnancy rate in oocyte donation programmes is 2447%, but even these pregnancies have a high rate of miscarriage, probably due to uterine factors. A possible future prospect is cryopreservation of ovarian tissue containing immature follicles before the onset of early menopause, but methods of replantation and in-vitro maturation still need to be developed. Should these autologous oocytes indeed be used in the future, affected women would need to undergo genetic counselling before conception, followed by prenatal assessment.
Document Type: Research article
Publication date: 2001-12-01
- Human Reproduction Update, first published in 1995, aims to provide invited, comprehensive, authoritative, up-to-date critical and balanced reviews covering all areas of human reproduction including reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology and counselling, ethics and social issues. These papers are peer-reviewed to the highest editorial and scientific standards. Human Reproduction Update is published on behalf of the European Society of Human Reproduction and Embryology (ESHRE).