Authors: J.A. Barritt; S. Willadsen; C. Brenner; J. Cohen

Source: Human Reproduction Update, Volume 7, Number 4, 1 June 2001 , pp. 428-435(8)

Publisher: Oxford University Press

Abstract:

This report details the use of cytoplasmic transfer in human oocytes. The introduction of a small amount of ooplasm from a donor oocyte or zygote may alter the function of oocytes, with probable deficiencies. Cytoplasmic transfer from fertile donor oocytes or zygotes into compromised oocytes from patients with recurrent implantation failure afterassisted reproduction has now led to the birth of nearly 30 healthy babies worldwide. Transfer of small amounts of cytoplasm probably involves mRNAs, proteins and mitochondria, as well as other factors and organelles. Even though the use of cytoplasmic transfer has been employed in several IVF clinics–-and pregnancies have resulted–-it is not known definitively whether the physiology of the early embryo is affected. This review outlines the experimental cytoplasmic transfer techniques and postulates the future impact in assisted reproduction.

Keywords: cytoplasmic transfer; human oocytes and embryos; h

Document Type: Original article

Affiliations: 1: Gamete and Embryo Research Laboratory, Institute for Reproductive Medicine and Science of Saint Barnabas, West Orange, New Jersey, 07052, USA

Publication date: 2001-06-01

More about this publication?

• Human Reproduction Update, first published in 1995, aims to provide invited, comprehensive, authoritative, up-to-date critical and balanced reviews covering all areas of human reproduction including reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology and counselling, ethics and social issues. These papers are peer-reviewed to the highest editorial and scientific standards. Human Reproduction Update is published on behalf of the European Society of Human Reproduction and Embryology (ESHRE).

Related content

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Library Science ,  Obstetrics & Gynecology
• By this author: J.A. Barritt ;  S. Willadsen ;  C. Brenner ;  J. Cohen

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers