Prediction of sperm retrieval in men with non-obstructive azoospermia using artificial neural networks: leptin is a good assistant diagnostic marker
Authors: Ma, Yi; Chen, Bin; Wang, HongXiang; Hu, Kai; Huang, YiRan
Source: Human Reproduction, Volume 26, Number 2, 7 February 2011 , pp. 294-298(5)
Publisher: Oxford University Press
At present, non-invasive methods are not comprehensive enough to enable urologists to predict sperm retrieval results accurately in patients with non-obstructive azoospermia (NOA). Our aim was to improve the prediction accuracy of sperm retrieval by using leptin and artificial neural networks (ANNs).
Data from May 2004 to July 2010 for 280 patients with NOA were reviewed and assigned into the training and testing set for ANNs. All patients underwent standard diagnostic infertility evaluation and testicular sperm extraction (TESE). Twelve factors were recorded as the input variables for ANNs:
All ANN models were better than FSH. ANN1 had the largest area under the curve (AUC =0.83) and demonstrated significant improvement compared with FSH (AUC =0.63, P< 0.01) and leptin (AUC =0.59, P< 0.01).
ANNs improve the prediction accuracy of sperm retrieval. Although the leptin AUC is low, combined use of leptin and FSH can significantly improve the prediction accuracy for sperm recovery in NOA patients. Leptin may be a good assistant marker for diagnosing NOA. However, studies with larger numbers of patients are required to confirm the improved predictive performance of ANNs.
Document Type: Research Article
Publication date: 7 February 2011
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.