Parental infertility and cerebral palsy in children
Authors: Zhu, Jin Liang; Hvidtjrn, Dorte; Basso, Olga; Obel, Carsten; Thorsen, Poul; Uldall, Peter; Olsen, Jrn
Source: Human Reproduction, Volume 25, Number 12, 11 December 2010 , pp. 3142-3145(4)
Publisher: Oxford University Press
Children born after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) have been reported to have a higher risk of cerebral palsy (CP), perhaps due to the higher frequency of preterm birth, multiple births or vanishing embryo in the pregnancies. However, it has been suggested that the underlying infertility may be part of the pathway. In this study, we examined whether untreated subfecundity (measured by time to pregnancy) or infertility treatment was associated with an increased risk of CP in the offspring.
Using the Danish National Birth Cohort (19972003), we compared children born after 02 months of waiting time to pregnancy (n 35 848) with those born after a time to pregnancy of 35 months (n 15 361), 612 months (n 11 528) and >12 months (n 7387), as well as those born after IVF/ICSI (n 3617), ovulation induction with or without intrauterine insemination (n 3000), and unplanned pregnancies (n 13 462). CP cases were identified through the Danish CP Register.
In total, 165 (0.18) children were diagnosed with CP in the entire cohort. We found no significant association between time to pregnancy and the risk of CP in children conceived spontaneously. Children born after IVF/ICSI had an increased risk of CP, even after adjustment for preterm birth and multiplicity (hazard ratio 2.30, 95 confidence interval 1.124.73).
Subfecundity per se did not appear to be associated with the risk of CP in children, whereas being born after IVF/ICSI conferred an increased risk.
Document Type: Research Article
Publication date: 11 December 2010
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.