A cost-effectiveness analysis of in-vitro fertilization by maternal age and number of treatment attempts
Authors: Griffiths, Alison; Dyer, Suzanne M.; Lord, Sarah J.; Pardy, Chris; Fraser, Ian S.; Eckermann, Simon
Source: Human Reproduction, Volume 25, Number 4, 5 April 2010 , pp. 924-931(8)
Publisher: Oxford University Press
Abstract:BACKGROUNDThe increase in use and costs of assisted reproductive therapies including in-vitro fertilization (IVF) has led to debate over public funding. A decision analytic model was designed to estimate the incremental cost-effectiveness of IVF by additional treatment programmes and maternal age.METHODSData from the Australian and New Zealand Assisted Reproductive Database were used to estimate incremental effects (live birth and other pregnancy outcomes) and costs for cohorts of women attempting up to three treatment programmes. A treatment programme included one fresh cycle and a variable number of frozen cycles dependent on maternal age.RESULTSThe incremental cost per live birth ranged from AU27 373 and AU31 986 for women aged 3033 on their first and third programmes to AU130 951 and AU187 515 for 4245-year-old women on their first and second attempts. Overall, these trends were not affected by inclusions of costs associated with ovarian hyperstimulation syndrome or multiple births.CONCLUSIONSThis study suggests that cost per live birth from IVF increases with maternal age and treatment programme number and indicates that maternal age has the much greater effect. This evidence may help decisionmakers target the use of IVF services conditional on societal willingness to pay for live births and equity considerations.
Document Type: Research article
Publication date: 2010-04-05
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.