Parental infertility and developmental coordination disorder in children
Authors: Zhu, Jin Liang; Obel, Carsten; Basso, Olga; Olsen, Jrn
Source: Human Reproduction, Volume 25, Number 4, 5 April 2010 , pp. 908-913(6)
Publisher: Oxford University Press
Abstract:BACKGROUNDIt has previously been reported that children born after infertility treatment had a slight delay in early motor milestones. In this study, we examined whether children of infertile couples with or without infertility treatment had a higher risk of developmental coordination disorder (DCD).METHODSWe used data on parental infertility and DCD among 23 167 singletons from the Danish National Birth Cohort (19962002). Data on time to pregnancy (TTP) and infertility treatment were collected early in pregnancy. Data on DCD in children were collected using the Developmental Coordination Disorder Questionnaire, filled in by the mothers during follow-up when the children were 7 years old. We used the recommended cut-off for the age group to classify children.RESULTSCompared with children born of fertile couples, children conceived after a waiting TTP of longer than 12 months had a slightly higher risk of DCD [odds ratio (OR) 1.35, 95 confidence interval (CI) 1.031.77], but the estimated OR was not significant in children born after infertility treatment (OR 1.19, 95 CI 0.861.66). None of the individual treatment procedures was significantly associated with a higher risk of DCD. Children of parents who had not planned their pregnancy showed no elevated risk.CONCLUSIONSOur findings are overall reassuring, although it is possible that low fecundity may be associated with a modestly increased risk of DCD.
Document Type: Research article
Publication date: 2010-04-05
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.