Twins born following assisted reproductive technology: perinatal outcome and admission to hospital

Authors: Hansen, Michle; Colvin, Lyn; Petterson, Beverly; Kurinczuk, Jennifer J.; de Klerk, Nicholas; Bower, Carol

Source: Human Reproduction, Volume 24, Number 9, 28 September 2009 , pp. 2321-2331(11)

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Abstract:

BACKGROUND

Compared with spontaneously conceived (SC) singletons, adverse perinatal outcome, neonatal intensive care unit (NICU) admission and hospital admission in infancy are more common in those born following Assisted Reproductive Technology (ART). Similar comparisons for twins have shown conflicting results.

METHODS

We investigated perinatal outcome and hospital admission during the first 3 years of life for all twin children born in Western Australia between 1994 and 2000 [700 ART, 4097 SC].

RESULTS

ART twins had a greater risk of adverse perinatal outcome including preterm birth, low birthweight and death compared with SC twins of unlike-sex. In their first year of life, ART twins had a longer birth admission; were 60 more likely to be admitted to a NICU; and had a higher risk of hospital admission. The increased risk of hospital admission continued in the second and third year but was not statistically significant in the third year.

CONCLUSIONS

Couples undertaking ART should be aware that in addition to the known increased perinatal risks associated with a twin birth, ART twins are more likely than SC twins to be admitted to a NICU and hospitalized in the first 3 years of life.

Keywords: assisted reproductive technology; hospital admission; IVF; morbidity; twins

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/dep173

Publication date: 2009-09-28

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Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

Twins born following assisted reproductive technology: perinatal outcome and admission to hospital

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