Authors: Abu-Musa, Antoine A.; Nassar, Anwar H.; Usta, Ihab M.

Source: Human Reproduction, Volume 23, Number 11, 6 November 2008 , pp. 2438-2443(6)

Publisher: Oxford University Press

Abstract:

BACKGROUND

Factors influencing a pregnant womans decision to accept prenatal testing are largely undefined. Our study aimed to compare the acceptance rate of prenatal diagnosis in women who conceived through IVF or ICSI (cases) with that of women who conceived spontaneously (controls).

METHODS

Retrospective chart review in Lebanon of all primiparas carrying singletons who were offered prenatal testing (triple screen/amniocentesis) from 20042007. The influence of IVF/ICSI on the acceptance of prenatal screening was evaluated.

RESULTS

336 pregnant women were offered prenatal testing (120 cases and 216 controls). Cases were less likely to perform prenatal testing compared with controls (52.5 versus 72.7; P < 0.001). The rate of utilization of prenatal testing was independent of the infertility cause. Multiple logistic regression analysis revealed that women who conceived through IVF/ICSI [odds ratio (OR) 0.427, 95 confidence interval (CI) 0.2520.724], those 35 years old (OR 0.184, 95 CI 0.1020.329) and lower socioeconomic class (OR 0.339, 95 CI 0.1970.584) were less likely to perform triple screen test, and women who conceived through IVF/ICSI (OR 0.354, 95 CI 0.1310.958) and those of lower socioeconomic class (OR 0.113, 95 CI 0.0330.403) were less likely to perform amniocentesis.

CONCLUSIONS

There was a significant difference in acceptance rate of prenatal diagnostic testing between women who conceived through IVF/ICSI and those who conceived spontaneously. Women who conceived through IVF/ICSI were less likely to opt for prenatal diagnosis even after controlling for confounding variables.

Keywords: IVF; triple screen; amniocentesis; spontaneous pregnancy

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/den291

Publication date: 2008-11-06

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

Related content

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Obstetrics & Gynecology
• By this author: Abu-Musa, Antoine A. ;  Nassar, Anwar H. ;  Usta, Ihab M.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers