Success rates and cost of a live birth following fresh assisted reproduction treatment in women aged 45 years and older, Australia 20022004
Authors: Sullivan, Elizabeth; Wang, Yueping; Chapman, Michael; Chambers, Georgina
Source: Human Reproduction, Volume 23, Number 7, 21 July 2008 , pp. 1639-1643(5)
Publisher: Oxford University Press
The aim of this study was to calculate assisted reproductive technology (ART) success rates for fresh autologous and donor cycles in women aged 45 and the resultant cost per live birth.
We performed a retrospective population-based study of 2339 ART cycles conducted in Australia, 20022004 to women aged 45 years. The cost-outcome study was performed on fresh autologous treatment cycles.
There were 1101 fresh autologous cycles initiated in women aged 45, with a pregnancy rate of 1.9 per 100 initiated cycles. There were 21 women who achieved a clinical pregnancy with 15 (71) ending in early pregnancy loss and 6 in live singleton births. The live birth rate following fresh autologous initiated cycles was 0.5 [95 confidence interval (CI): 0.11.0]. Fresh donor recipients had an higher live birth rate of 19.1 (95 CI: 15.123.2) (odds ratio 43.2; 95 CI: 18.6100.3) compared with women having fresh autologous cycles. The average cost of a live birth following fresh autologous cycles was 753 107.
The success rate of fresh autologous treatment for women aged 45 years was <1. The very high cost of a live birth reflects a treatment failure rate of >99. The ART profession should counsel patients of the reality of the technology before the patients consent to treatment.
Document Type: Research Article
Publication date: 2008-07-21
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.