What next for preimplantation genetic screening?
Authors: Harper, Joyce; Sermon, Karen; Geraedts, Joep; Vesela, Katerina; Harton, Gary; Thornhill, Alan; Pehlivan, Tugce; Fiorentino, Francesco; SenGupta, Sioban; de Die-Smulders, Christine; Magli, Cristina; Moutou, Celine; Wilton, Leeanda
Source: Human Reproduction, Volume 23, Number 3, 9 March 2008 , pp. 478-480(3)
Publisher: Oxford University Press
Abstract:Preimplantation genetic diagnosis for aneuploidy screening (preimplantation genetic screeningPGS) has been used to detect chromosomally normal embryos from subfertile patients. The main indications are advanced maternal age (AMA), repeated implantation failure, repeated miscarriages and severe male factor infertility. Many non-randomized PGS studies have been published and report an increase in implantation rate, and/or a decrease in miscarriage rate. Recently, two randomized controlled trials have been conducted on patients with AMA as the only indication. Neither study showed a benefit in performing PGS using live birth rate as the measure of success. The debate on the usefulness of PGS is ongoing; the only effective way to resolve the debate is to perform more well-designed and well-executed randomized clinical trials.
Document Type: Opinion
Publication date: 2008-03-09
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.
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- In this Subject: Anatomy & Physiology , Obstetrics & Gynecology
- By this author: Harper, Joyce ; Sermon, Karen ; Geraedts, Joep ; Vesela, Katerina ; Harton, Gary ; Thornhill, Alan ; Pehlivan, Tugce ; Fiorentino, Francesco ; SenGupta, Sioban ; de Die-Smulders, Christine ; Magli, Cristina ; Moutou, Celine ; Wilton, Leeanda