Embryo viability and metabolism: obeying the quiet rules
Authors: Leese, Henry J.; Sturmey, Roger G.; Baumann, Christoph G.; McEvoy, Tom G.
Source: Human Reproduction, Volume 22, Number 12, 16 December 2007 , pp. 3047-3050(4)
Publisher: Oxford University Press
It has been proposed that preimplantation embryo viability during culture and following embryo transfer is associated with a quiet metabolism. Viable embryos may be better equipped to contend with damage to the genome, transcriptome and proteome, or they may possess less damage than non-viable embryos.
Much of the data for the quiet embryo hypothesis was obtained in the human and mouse. In this article, evidence is reviewed suggesting that the quiet hypothesis may equally be applied to reproduction in livestock, which can provide good models for the human.
Data, particularly for the sheep and cow, suggest that a quiet metabolism during early embryo development is consistent with successful embryo development. Conversely, an active metabolism is associated with sub-optimal outcomes in later life.
The challenge is to identify the range of values for a given marker within which an embryo has a high chance of giving rise to healthy offspring. We also speculate on the ways in which such a metabolic profile might be encouraged and the implications for weight loss in obese women prior to conception.
Document Type: Opinion
Publication date: 2007-12-16
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.