Lipiodol fertility enhancement: two-year follow-up of a randomized trial suggests a transient benefit in endometriosis, but a sustained benefit in unexplained infertility
Authors: Johnson, N.P.; Kwok, R.; Stewart, A.W.; Saththianathan, M.; Hadden, W.E.; Chamley, L.W.
Source: Human Reproduction, Volume 22, Number 11, 12 November 2007 , pp. 2857-2862(6)
Publisher: Oxford University Press
Abstract:BACKGROUNDA New Zealand randomized trial has shown that lipiodol treatment enhances fertility with high short-term effectiveness for women with endometriosis.METHODSAn open randomized trial in a single-centre secondary- and tertiary-level infertility service assessing lipiodol flushing versus no intervention. A total of 158 women with unexplained infertility (62 women with mild endometriosis and 96 women with pure unexplained infertility) were evaluated at 24 months after trial entry. The main outcome measure was clinical pregnancy, assessed using a Cox proportional hazards regression model.RESULTSThere was a significant benefit in overall pregnancy rate following lipiodol [hazard ratio 2.0, 95 confidence interval (CI) 1.33.2]. Among women with endometriosis, the benefit in pregnancy rate seen in the first 6 months following lipiodol (hazard ratio 5.4, 95 CI 2.114.2) was not present at 624 months (hazard ratio 0.6, 95 CI 0.22.1). There was a more consistent effect of lipiodol on fertility throughout the 24-month follow-up among women with unexplained infertility (hazard ratio 2.0, 95 CI 1.13.5). CONCLUSIONS: Lipiodol flushing is effective at enhancing fertility not only for women with endometriosis, but also for those with pure unexplained infertility.
Document Type: Research article
Publication date: 2007-11-12
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.