Heritability of reproductive hormones in adult male twins
Authors: Kuijper, E.A.M.; Lambalk, C.B.; Boomsma, D.I.; van der Sluis, S.; Blankenstein, M.A.; de Geus, E.J.C.; Posthuma, D.
Source: Human Reproduction, Volume 22, Number 8, 21 August 2007 , pp. 2153-2159(7)
Publisher: Oxford University Press
Proper functioning of the male reproductive axis depends on complex feedback systems between several hormones. In this study, the genetic contribution of various endocrine components of the hypothalamicpituitarytesticular axis is evaluated and previously observed differences in FSH and inhibin B levels between mono- (MZ) and dizygotic (DZ) twins are re-investigated.
Inhibin B, FSH, LH, sex hormone-binding globulin (SHBG) and testosterone levels were assayed in 128 adult males (20 MZ twin pairs, 7 single MZ twins, 10 DZ twin pairs, 27 single DZ twins and 34 siblings of twins, constituting 10 sibling pairs), aged 15.668.7 years. Hormone levels were compared across zygosity groups and heritability estimates were obtained using maximum likelihood variance component analysis.
Heritability estimates ranged from 56 (testosterone) to 81 (inhibin B and SHBG). For LH and FSH, the heritability was estimated at 68 and 80 respectively. No mean differences in hormone levels were observed across groups.
All measured hormones are highly heritable. A difference in the FSH-inhibin B feedback system between DZ twin males and MZ twin males could not be confirmed.
Document Type: Research Article
Publication date: 2007-08-21
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.