GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study
Authors: Pirard, C.; Donnez, J.; Loumaye, E.
Source: Human Reproduction, Volume 21, Number 7, July 2006 , pp. 1894-1900(7)
Publisher: Oxford University Press
Abstract:BACKGROUND: The aim of the study was to investigate whether intranasal (IN) administration of a GnRH agonist could provide luteal support in IVF/ICSI patients. METHODS: Controlled ovarian hyperstimulation (COH) was performed using hMG/FSH and a GnRH antagonist. Patients were then randomly allocated to either 10 000 IU hCG, followed by vaginal administration of micronized progesterone (3× 200 mg/day) (group A), or 200 µg IN buserelin followed by either 100 µg every 2 days (group B), or 100 µg every day (group C), or 100 µg twice a day (group D), or 100 µg three times a day (group E). Luteal support was continued for 15 days. RESULTS: Twenty-three patients were randomized. Groups B and C were discontinued prematurely in view of the short luteal phase. The luteal phase was significantly shorter in groups B, C and D, whereas group E was comparable with group A, 13.5 and 13.0 days, respectively. In the mid-luteal phase, median progesterone levels were significantly lower in groups B, C and D, whereas group E was comparable with group A, 68.9 and 98.0 ng/ml, respectively. Estradiol (E
Document Type: Research Article
Publication date: 2006-07-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.