Activin receptor expression and induction of apoptosis in rat blastocysts in vitro
Authors: Debiève, F.; Hinck, L.; Biard, J.-M.; Bernard, P.; Hubinont, C.
Source: Human Reproduction, Volume 21, Number 3, March 2006 , pp. 618-623(6)
Publisher: Oxford University Press
Abstract:BACKGROUND: Apoptosis, a process of normal embryonic development, is enhanced in blastocyst from diabetic rats. Nevertheless, glucose seems not to be the only factor involved. Activin A, a TGF- family member, is also increased in maternal serum from diabetic pregnancy. METHODS: Flushing medium, blastocysts and uterine cells were obtained from 5 day old pregnant rats. The presence of activin A in flushing medium was investigated by western blotting. RT–PCR was used to test for the presence of activin
Document Type: Research Article
Publication date: 2006-03-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.