Authors: Bahamondes, Luis; Monteiro-Dantas, Cecilia; Espejo-Arce, Ximena; dos Santos Fernandes, Arlete M.; Lui-Filho, Jeffrey F.; Perrotti, Marcos; Petta, Carlos A.

Source: Human Reproduction, Volume 21, Number 2, February 2006 , pp. 466-470(5)

Publisher: Oxford University Press

Abstract:

BACKGROUND: The aim of the study was to compare bone mineral density (BMD) before insertion and at 18 months of use of etonorgestrel- and levonorgestrel-releasing contraceptive implants. METHODS: One hundred and eleven women, 19–43 years of age, were randomly allocated to two groups: 56 to etonorgestrel and 55 to levonorgestrel. BMD was evaluated at the midshaft of the ulna and at the distal radius of the non-dominant forearm using dual-energy X-ray absorptiometry before insertion and at 18 months of use. RESULTS: There was no difference in baseline demographic or anthropometric characteristics, or in BMD of users of either model of implant. BMD was significantly lower at 18 months of use at the midshaft of the ulna in both groups of users. However, no difference was found at the distal radius. Multiple linear regression analysis showed that the variables associated with BMD at 18 months of use in both implant groups were baseline BMD, body mass index (BMI) and difference in BMI (0 versus 18 months of use). CONCLUSIONS: Women of 19–43 years of age using either one of the implants showed lower BMD at 18 months of use at the midshaft of the ulna, however, without a difference at the distal radius.

Keywords: bone mineral density; contraceptive implants; etonorgestrel; levonorgestrel

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/dei358

Publication date: 2006-02-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

Related content

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Obstetrics & Gynecology
• By this author: Bahamondes, Luis ;  Monteiro-Dantas, Cecilia ;  Espejo-Arce, Ximena ;  dos Santos Fernandes, Arlete M. ;  Lui-Filho, Jeffrey F. ;  Perrotti, Marcos ;  Petta, Carlos A.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers