Authors: Hvidtjørn, Dorte¹; Grove, Jakob¹; Schendel, Diana¹; Væth, Michael²; Ernst, Erik³; Nielsen, Lene¹; Thorsen, Poul¹

Source: Human Reproduction, Volume 20, Number 9, September 2005 , pp. 2550-2551(2)

Publisher: Oxford University Press

Abstract:

BACKGROUND: In a Danish population-based cohort study assessing the risk of cerebral palsy in children born after IVF, we made some interesting observations regarding ‘vanishing co-embryos’. METHODS and RESULTS: All live-born children born in Denmark from 1 January 1995 to 31 December 2000 were included in this analysis. The children conceived by IVF/ICSI (9444) were identified through the IVF Register, the children conceived without IVF/ICSI (395 025) were identified through The Danish Medical Birth Register. Main outcome measure was the incidence of cerebral palsy. Within the IVF/ICSI children we found indications of an increased risk of cerebral palsy in those children resulting from pregnancies, where the number of embryos transferred was higher than the number of children born. CONCLUSIONS: The association between vanishing embryo syndrome and incidence of cerebral palsy following IVF requires further investigation in larger, adequately powered, studies.

Keywords: cerebral palsy; IVF; vanishing embryo syndrome

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/dei092

Affiliations: 1: NANEA, Department of Epidemiology, Institute of Public Health, University of Aarhus, Paludan-Müllers Vej 17, DK-8000 Aarhus C, Denmark, 2: Department of Biostatistics, Institute of Public Health, University of Aarhus and 3: Fertility Section, Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark

Publication date: 2005-09-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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• In this Subject: Anatomy & Physiology ,  Obstetrics & Gynecology
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