Hypothalamic–pituitary–gonadal axis function after successful kidney transplantation in men and women
Authors: Tauchmanovà, Libuse1; Carrano, Rosa2; Sabbatini, Massimo2; De Rosa, Michele1; Orio, Francesco1; Palomba, Stefano3; Cascella, Teresa1; Lombardi, Gaetano1; Federico, Stefano2; Colao, Annamaria1
Source: Human Reproduction, Volume 19, Number 4, April 2004 , pp. 867-873(7)
Publisher: Oxford University Press
Abstract:BACKGROUND: Renal transplantation (RT) is the most common solid organ transplant procedure. Several studies have reported on gonadal function in male and female RT recipients with controversial results. METHODS: Forty consecutive patients (20 male, 20 female) with a fully functioning allograft (serum creatinine 0.8–1.3 mg/dl) for at least 15 months after RT were included in the study. Their ages ranged from 23 to 44 years (median 38) and their post‐RT follow‐up lasted 15–86 months (median 23). FSH, LH, prolactin, 17‐‐estradiol, testosterone, androstenedione and dehydroepiandrostrone were determined in all patients and compared with a group of 80 healthy subjects. Pelvic ultrasonography was performed in all participants. RESULTS: Testosterone was below the normal range in 70% of male patients and within the lowest third in the remainder; a lack of LH increase indicated an inhibition of the reproductive axis. Male testosterone values were negatively influenced by calcineurine inhibitors treatment (P < 0.005), but positively influenced by a better graft function (P < 0.0001). Testicular and prostate volumes were reduced with respect to controls, with the latter related to circulating testosterone levels. Ten of the women (50%) had menstrual cycle disorders after RT, three being affected by transient, and three by persistent, amenorrhea. Another two patients had had transient polymenorrhea. In four women (20%), a premature ovarian failure was diagnosed. No relationship was found between female reproductive function and age, graft function or duration of the post‐transplant period. Prolactin was lower in patients on calcineurin inhibitors (P < 0.01). CONCLUSIONS: Abnormalities of the reproductive system were frequent after successful RT in both genders.
Document Type: Research Article
Affiliations: 1: Department of Molecular and Clinical Endocrinology and Oncology, 2: Department of Nephrology, University Federico II of Naples and 3: Department of Gynecology and Obstetrics, University Magna Graecia, Catanzaro, Italy
Publication date: April 2004
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.
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- In this Subject: Anatomy & Physiology , Obstetrics & Gynecology
- By this author: Tauchmanovà, Libuse ; Carrano, Rosa ; Sabbatini, Massimo ; De Rosa, Michele ; Orio, Francesco ; Palomba, Stefano ; Cascella, Teresa ; Lombardi, Gaetano ; Federico, Stefano ; Colao, Annamaria