Authors: Miriam Almagor¹; Albert Hazav²; Haim Yaffe²

Source: Human Reproduction, Volume 19, Number 1, January 2004 , pp. 104-106(3)

Publisher: Oxford University Press

Abstract:

BACKGROUND: The complex regulation of endometrial receptivity and embryo implantation involves cytokines, several of which are stimulators of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the concentrations of serum CRP in women treated by IVF. METHODS: Seventy-two women who underwent IVF treatment were prospectively studied. The levels of serum CRP were evaluated on the following days: oocyte retrieval, embryo transfer, 5, 6 or 7 days afterwards and 12 days after embryo transfer. RESULTS: CRP levels increased from 6.8 ± 9.5 mg/l on oocyte retrieval day to 14.6 ± 12.5 mg/l on days 5–7 post-transfer (P < 0.0001). The ratios of CRP levels for transfer day/pick-up day were 1.2 in women who conceived versus 2.5 in the non-pregnant group (P = 0.01). CONCLUSION: In women treated by IVF the concentrations of CRP in blood increase significantly during the first week following oocyte retrieval. Successful outcome is associated with a relative small increment in CRP on the day of embryo transfer.

Keywords: C-reactive protein/cytokine/IVF/uterine receptivit

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/deh036

Affiliations: 1: Division of Clinical Laboratories and 2: Department of Obstetrics and Gynecology, Bikur Cholim Hospital, Jerusalem, Israel

Publication date: 2004-01-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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